Lysosomal dysregulation in the murine App NL-G-F/NL-G-F model of Alzheimer's disease.

Lauren S Whyte,Sofia Hassiotis,Kathryn J Hattersley,Kim M Hemsley,John J Hopwood,Adeline A Lau,Timothy J Sargeant

Neuroscience（2020）

引用 9|浏览28

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摘要

•LAMP1 accumulates at amyloid beta plaques in AppNL-G-F/NL-G-F (knock-in) mouse brain.•Lysosomal hydrolases are enriched at amyloid beta plaques in AppNL-G-F/NL-G-F mice.•Some lysosomal network proteins are elevated in AppNL-G-F/NL-G-F cortex.•Lysosomal network dysfunction in AppNL-G-F/NL-G-F mice resembles human AD.

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关键词

AD,APP,GFAP,GLB1,IBA1,LAMP1,LC3,NEUN,NFL,PBS

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