Stereoselective separation of isomeric sertraline with analytical countercurrent chromatography.

Wenyu Sun,Yang Jin,Chaoyue Wang,Shanshan Zhao,Xiang Wang,Meng Luo,Jizhong Yan,Shengqiang Tong

Journal of Chromatography A（2020）

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摘要

•Stereoselective liquid-liquid extraction of isomeric sertraline was investigated.•An unusual stereoselective combination was found when sodium carbonate buffer was used.•Stereoselective separation by analytical countercurrent chromatography was established.•Methyl-β-cyclodextrin was selected for stereoselective separation by countercurrent chromatography.

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关键词

Countercurrent chromatography,Hydroxypropyl-β-cyclodextrin,Isomeric sertraline,Methyl-β-cyclodextrin,Stereoselective liquid-liquid extraction

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