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In vitro response and gene expression of human retinal Muller cells treated with different anti-VEGF drugs

Javier Caceres-del-Carpio,M. Tarek Moustafa,Jaime Toledo-Corral,Mohamed A. Hamid,Shari R. Atilano,Kevin Schneider,Paula S. Fukuhara,Rodrigo Donato Costa,J. Lucas Norman,Deepika Malik,Marilyn Chwa,David S. Boyer,G. Astrid Limb,M. Cristina Kenney,Baruch D. Kuppermann

EXPERIMENTAL EYE RESEARCH（2020）

Cited 6|Views32
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Abstract
•Human retinal Müller cells (MIO-M1) were treated with 4 different anti-VEGF drugs.•Cultures had decreased metabolism, viability and mitochondrial membrane potential.•Treatment led to higher levels of ROS and apoptosis.•Altered expression of angiogenesis, pro-apoptosis and inflammatory genes were found.•Anti-VEGF drugs may contribute to cytotoxicity associated with chronic injections.
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