Immunosuppressive Drugs Alter α1-Antitrypsin Production in Hepatocytes: Implications for Epithelial Gap Repair.

IdoBrami,Dor Ini, Nofit Sassonker, Melody Zaknoun,Tsila Zuckerman,Eli C Lewis

Biology of Blood and Marrow Transplantation（2020）

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摘要

•Rapamycin decreases α1-antitrypsin production by hepatocytes under inflammation.•Mycophenolate mofetil inhibits wound repair in intestinal epithelial cell line.•Exogenous α1-antitrypsin enhances allo-HSCT recipients’ sera wound repair capability.

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关键词

Acute-phase response,Autoinflammation,Hepatotoxicity,Immunomodulation,Wound healing

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