Convergent Synthesis of Polysubstituted Furans Via Catalytic Phosphine Mediated Multicomponent Reactions
Molecules/Molecules online/Molecules annual(2019)
Abstract
Tri- or tetrasubstituted furans have been prepared from terminal activated olefins and acyl chlorides or anhydrides by a multicomponental convergent synthesis mode. Instead of stoichiometric nBu3P, only catalytic nBu3P or nBu3P=O is needed to furnish the furans in modest to excellent yields with a good functional group tolerance under the aid of reducing agent silane. This synthetic method features a silane-driven catalytic intramolecular Wittig reaction as a key annulation step and represents the first successful application of catalytic Wittig reaction in multicomponent cascade reaction.
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Key words
polysubstituted furans,multicomponent reaction,silanes,phosphine oxides,catalytic Wittig reaction
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