GPR43 regulates HBV X protein (HBx)-induced inflammatory response in human LO 2 hepatocytes.

Tao He,Ning Zhang,Li Wang,Baishun Wan,Xiaoqian Wang,Ling Zhang

Biomedicine & Pharmacotherapy（2020）

引用 9|浏览15

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摘要

•GPR43 is strongly expressed in LO2 cells and is reduced by HBx.•Agonism of GPR43 prevents HBx-induced oxidative stress.•Agonism of GPR43 ameliorates HBx-induced expression of IL-6, MCP-1, CXCL2, and HMGB-1.•The effects of GPR43 agonism are mediated through the NF-κB pathway.

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关键词

GPR43,Free fatty acid receptor 2,Hepatitis B virus (HBV),Hepatocellular carcinoma,HCC,G coupled-protein receptor agonist,Hepatitis B protein X (HBx)

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