Catalytic Intermolecular C(Sp(3))-H Amination With Sulfamates For The Asymmetric Synthesis Of Amines
ORGANIC PROCESS RESEARCH & DEVELOPMENT(2020)
Abstract
A practical catalytic asymmetric benzylic C(sp(3))-H amination through the intermolecular insertion of a rhodium-bound nitrene species is reported. The reaction of various substrates (used as the limiting component) with the readily accessible sulfamate PfbsNH(2) and the chiral rhodium(II) catalyst Rh-2 (S-tfptad)(4) in the presence PhI(OPiv)(2) can be performed on a multigram scale, affording the corresponding benzylic amines with high levels of efficiency and enantiocontrol. This process offers new opportunities for the asymmetric synthesis of amines.
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Key words
carbon-nitrogen bond, C(sp(3))-H functionalization, amination, catalysis, asymmetric, rhodium, hypervalent iodine
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