New 3,4-bis(indol-1-yl)maleimides as protein kinase inhibitors

Alexey A. Panov,Sergey A. Lakatosh,Michael H. G. Kubbutat,Lyubov G. Dezhenkova,Frank Totzke, Kristof Schechtel

Chemistry of Heterocyclic Compounds（2019）

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摘要

Several previously unknown derivatives of 3,4-bis(indol-1-yl)maleimide, as well as 3-(2,3-dihydroindol-1-yl)-4-(indol-1-yl)maleimide were synthesized as potential analogs for a known series of protein kinase inhibitors BIS I, IV, IX containing the structural motif of 3,4-bis(indol-3-yl)maleimide. The activity of these synthesized compounds was characterized with regard to several human protein kinases and their cytotoxicity was determined.

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关键词

indole,indolylmaleimides,antitumor drugs,protein kinases,protein kinase inhibitors

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