Synthesis and chemical transformations of diazolyl α,α-difluoroacetates

Journal of Fluorine Chemistry(2020)

Cited 7|Views12
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Abstract
•An approach to a series of diazolyl α,α-difluoroacetates is developed.•The strategy is based on deoxofluorination of diazolyl glyoxylates with morph-DAST.•Two protocols were developed since some glyoxylates were not reactive upon typical conditions.•Difluoroacetates were transformed to the building blocks promising for medicinal chemistry.
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Key words
Deoxofluorination,Nitrogen heterocycles,gem-Difluorinated compounds,Building blocks,Azoles
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