10PPrognosis and effect of adjuvant treatment in small, node(-), HER2(+) breast cancer

Background There remains uncertainty regarding prognosis and treatment effect in small, node negative breast cancer. We described overall prognosis of small ( Methods We identified patients who fulfilled inclusion criteria (curative surgery, Results A total of 429 patients (pT1a=205, pT1b=222) were identified. In patients with pT1a, only 1 patient experienced systemic recurrence and death. No difference was observed in DFS and OS between patients with adjuvant chemotherapy and/or adjuvant trastuzumab. In pT1b, HR(-) patients (N = 52), longer DFS was observed in patients who received adjuvant chemotherapy (p = 0.013). There was no difference in DFS according to trastuzumab treatment (p = 0.441). No difference was found according to adjuvant treatment in overall or HR(+) pT1b patients. Conclusions In conclusion, our result showed overall prognosis of small( Legal entity responsible for the study The authors. Funding Has not received any funding. Disclosure All authors have declared no conflicts of interest.