Superoxide Drives Pi3 Kinase Mediated Mitochondria Transfer From The Bone Marrow Microenvironment To Hematopoietic Stem Cells In Response To Salmonella Typhimurium

Hematopoietic stem cells (HSC) undergo rapid expansion in response to stress stimuli. Specifically, there is rapid expansion of leukocytes in response to pathogenic bacteria which underpins the mammalian response to infection. Presently, the mechanisms by which HSC metabolism is regulated in response to the challenges of pathogenic stress are not fully understood. Here we investigate the bioenergetic processes which facilitate the HSCs expansion in response to infection.