Early Hyperbilirubinemia Is An Independent Predictor Of Outcome After Allogeneic Stem Cell Transplantation And Correlates With Markers Of Endothelial Cell Dysfunction

Background: Hyperbilirubinemia occurs frequently in the early phase after allogeneic stem cell transplantation (alloSCT). In the present study we analysed whether high bilirubin levels until day +28 after alloSCT are associated with clinical outcome independent of liver toxicity and clinically defined diseases, such as sinusoidal obstruction syndrome (SOS/VOD), transplantation-associated thrombotic microangiopathy (TAM) or steroid-refractory acute graft-versus-host disease (refrGVHD).