Microrna-191 Regulates T-Cell Clonal Expansion During Graft-Versus-Host Disease
BLOOD(2019)
Abstract
Allogeneic hematopoietic cell transplantation is a potentially curative treatment choice for a wide variety of hematological malignancies. However, graft-versus-host disease (GVHD), which is mediated by donor alloreactive T cells, limits the success of this procedure. Previous studies have demonstrated that several microRNAs (miRs) modulate graft-versus-host disease. miR-191 was previously reported to be able to support T cell survival after TCR stimulation. We hypothesize that miR191 regulates T cell response during GVHD.
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Key words
t-cell,graft-versus-host
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