Aav8-Specific Immune Adsorption Column: A Treatment Option For Patients With Pre-Existing Anti-Aav8 Neutralizing Antibodies
BLOOD(2019)
Abstract
Background: Pre-existing neutralizing antibodies (NAbs) are a major hurdle in adeno-associated virus 8 (AAV8) gene therapy and result in patients being excluded from clinical trials. Prevalence data published by Kruzik et al. suggest that up to 50% of patients have biologically relevant NAbs against AAV8, excluding them from current clinical trials. We developed a strategy to circumvent pre-existing anti-AAV8 immunity and specifically remove anti-AAV8 antibodies.
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Adoptive Cell Transfer
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