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Detection of autoantibodies in central nervous system inflammatory disorders: Clinical application of cell-based assays

Rachel Dias Molina,Lucas Piccoli Conzatti,Ana Paula Bornes da Silva,Leise Daniele Sckenal Goi,Bruna Klein da Costa,Denise Cantarelli Machado,Douglas Kazutoshi Sato

Multiple Sclerosis and Related Disorders（2020）

Cited 8|Views5
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Abstract
•Autoantibodies have emerged as biomarkers for neuroimmunological diseases.•Cell-based assays (CBA) are useful in clinical practice for cell-surface antigens.•ELISA and western-blot may be inaccurate for conformational sensitive antibodies.•CBA is used for detection of aquaporin-4-IgG, MOG-IgG and other autoantibodies.
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Key words
Cell-based assay,Neuromyelitis optica spectrum disorders,Aquaporin-4,Myelin oligodendrocyte glycoprotein,Autoimmune Encephalitis
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