Granulocyte Transfusions In A Cohort Of Neutropenic Patients With Life-Threatening Infections And Hematologic Diseases

Granulocyte transfusions are inconsistently used despite observational evidence of their efficacy (Seidel et al, 2008). The Resolving Infection in Neutropenia with Granulocytes (RING) trial was incomplete due to poor enrollment and thus was underpowered to assess efficacy of granulocytes in adults with neutropenia and severe infection unresponsive to anti-microbials (Price et al, 2015). Post-hoc analysis showed a group of patients had better clinical responses with higher doses of granulocytes. We hypothesized that patients treated at Stanford University with higher doses of granulocytes had better clinical outcomes than those patients who received lower doses of granulocytes.