Relative Depletion Of Soluble Interleukin 6 Receptors Abolished The Development Of Cytokine Release Syndrome After Cart19/22 And Lenalidomide Treatment For Lymphoma

Cytokine release syndrome (CRS) is among the most representative toxicities of chimeric antigen receptor T (CART) cell therapies against non-Hodgkin's lymphoma (NHL). However, the mechanism of CRS is not fully elucidated. Interleukin-6 (IL-6) has been reported as a key factor in the development of CRS. We here present a novel mechanism of CRS emphasizing a balance between IL-6 and soluble IL-6 receptors (sIL-6Rs), essential amplifiers for IL-6-mediated inflammatory responses.