Whole-Body and Adipose Tissue-Specific Mechanisms Underlying the Metabolic Effects of Fibroblast Growth Factor 21 in the Siberian Hamster

Jo E. Lewis,Chloe Monnier,Hayley Marshall,Maxine Fowler, Rebecca Green,Scott Cooper,Aristeidis Chiotellis,Jeni Luckett,Alan C. Perkins,Tamer Coskun,Andrew C. Adams,Ricardo J. Samms,Francis J.P. Ebling,Kostas Tsintzas

Molecular Metabolism（2020）

引用 12|浏览44

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摘要

•FGF21 increases glucose and lipid uptake in adipose tissue.•The selective FGF21-induced increase in lipid uptake in BAT may fuel thermogenesis.•Unlike BAT, glucose uptake in WAT may be used for lipogenesis.

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关键词

FGF21,β-klotho,White adipose tissue,Brown adipose tissue,Glucose uptake,Lipid uptake

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