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Blocking Vascular Niche E-Selectin Dampens Aml Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting Mapk/Erk And Pi3k/Akt Signalling Pathways

Ingrid G Winkler,Valerie Barbier,Joshua Tay,Jean-Pierre Levesque,John L. Magnani,Corrine E Fiveash,Johanna D Erbani

BLOOD（2019）

Cited 3|Views19
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Abstract
We have previously shown vascular E (endothelial)-selectin to play a key role in niche-mediated chemo-resistance in Acute Myeloid Leukaemia (AML). Now we report that the cell surface glycosylation of AML blasts -and thus their E-selectin-binding potential- alters during therapy and queried whether these variations influence treatment outcome.
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Key words
inhibiting mapk/erk,stem,e-selectin
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