Hydroxyurea Reverses Dysfunctional Ubiquitin-Proteasomal System In Sickle Cell Disease And Suppresses Posttranslational Alterations In Hemoglobin And Cell Membranes

Swee Lay Thein,Arun S Shet,Michael Brad Strader, Fanato Meng,Michael Heaven,Jana Sirsendu,Abdu Alayash

BLOOD（2019）

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摘要

HYDROXYUREA REVERSES DYSFUNCTIONAL UBIQUITIN-PROTEASOMAL SYSTEM IN SICKLE CELL DISEASE AND SUPPRESSES POSTTRANSLATIONAL ALTERATIONS IN HEMOGLOBIN AND CELL MEMBRANES

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关键词

sickle cell disease,hemoglobin,ubiquitin-proteasomal

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