Novel high-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification of BCR-ABL and Bruton's tyrosine kinase inhibitors and their three active metabolites in human plasma.

Yuji Mukai,Tatsunari Yoshida,Takeshi Kondo,Nobuo Inotsume,Takaki Toda

Journal of Chromatography B（2020）

引用 23|浏览8

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摘要

•Method for simultaneous determination of six TKIs and three metabolites in plasma.•A simple extraction procedure is required.•The method is applicable to the analysis of clinical samples.

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关键词

Ctrough,DHI,HPLC,IS,IS-norm,LC–MS/MS,LLOQ,ME,MF,MRM,N-DI,N-DP,QC,%RE,%RSD,SPE,MTBE,TDM,TKI

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