Inhibition of medaka ovulation by gap junction blockers due to its disrupting effect on the transcriptional process of LH-induced Mmp15 expression.

Akane Hagiwara,Katsueki Ogiwara,Natsu Sugama,Masakane Yamashita,Takayuki Takahashi

General and Comparative Endocrinology（2020）

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摘要

•Gap junction blocker carbenoxolone strongly inhibited medaka ovulation.•Carbenoxolone specifically inhibited mmp15/Mmp15 expression in ovulating follicles.•Carbenoxolone inhibited the follicular expression of both Cdk9 and Ccni mRNA.•Carbenoxolone inhibited Pgr phosphorylation.•Connexins 34.5 and 35.4 were dominantly expressed in the ovulating follicles.

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关键词

Medaka ovulation,Gap junction blocker,Mmp15,Pgr phosphorylation,Cdk9,Cyclin I

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