Early Life Exposure To Coal Mine Fire And Tobacco Smoke Affect Subclinical Vascular Function
ARCHIVES OF DISEASE IN CHILDHOOD(2020)
摘要
Objective To evaluate whether vascular health in young children was associated with exposure to a 6-week episode of coal mine fire smoke or environmental tobacco smoke (ETS) in a retrospective cohort study.Methods Three years after a coal mine fire in Victoria, Australia, we investigated the vascular health of children either in utero (n=75) or aged <2 years (postnatal exposure, n=96) at the time of the fire. The outcomes were the carotid intima-media thickness (IMT) and pulse wave velocity (PWV). The mean and peak daily particulate matter <2.5 mu m in diameter (PM2.5) exposures were estimated based on their daily locations throughout the fire period. Multivariable linear regression models were used to test for associations between the fire-related PM2.5 and outcomes adjusted for relevant covariates including ETS.Results In the postnatal-exposure group, each 10 mu g/m(3) increase in mean PM2.5 level was independently positively associated with PWV (beta=0.116, p=0.028). When these two groups were combined, there was an association between mean PM2.5 and increased PWV in those children who had ETS exposure (beta=0.148, p=0.033) or whose mothers smoked (beta=0.151, p=0.011), but not in those not exposed to ETS or maternal smoking.Conclusions Three years after a coal mine fire, infants aged up to 2 years at the time of exposure have increases in vascular stiffness. Although no adverse effects were observed in the in uterus exposure group, further follow-up study is needed to elucidate the long-term effects of coal mine fire smoke exposure.
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关键词
air pollution,coalmine fire smoke,environmental tobacco smoke,maternal smoking,vascular disease
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