Discovery of novel 2,4-disubstituted pyrimidines as Aurora kinase inhibitors.
Bioorganic & Medicinal Chemistry Letters（2020）
Abstract
•Some novel 2,4-disubstituted pyrimidine derivatives showed potent antiproliferative activities.•Compound 12a displayed potent Aurora kinases activities.•Compound 12a induced apoptosis by regulating Bax and Bcl-xl.•Compound 12a had good binding modes with Aurora A and Aurora B.•Compound 12a exhibited good druglikeness using SwissADME prediction.
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Key words
Aurora kinase,Pyrimidine,Apoptosis,Anticancer
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