Erythropoiesis defect observed in STAT3 GOF patients with severe anemia.

Andrea A Mauracher, Julia J M Eekels,Janine Woytschak, Audrey van Drogen,Alessandra Bosch,Seraina Prader,Matthias Felber, Maximillian Heeg,Lennart Opitz,Johannes Trück, Silke Schroeder, Eva Adank,Adam Klocperk,Eugenia Haralambieva, Dieter Zimmermann,Sofia Tantou, Kosmas Kotsonis, Aikaterini Stergiou,Maria G Kanariou,Stephan Ehl,Onur Boyman,Anna Sediva,Raffaele Renella,Markus Schmugge,Stefano Vavassori,Jana Pachlopnik Schmid

The Journal of allergy and clinical immunology（2019）

引用 16|浏览17

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摘要

STAT3 mediates inflammation and modulates immunity. We found that in addition to its role in autoimmunity, over-activated STAT3 interferes in early erythro-myeloid precursor development and reduces commitment towards the erythroid lineage by interfering with the erythropoietin-STAT5 signalling pathway.

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