Histone H2A-peptide-hybrided upconversion mesoporous silica nanoparticles for bortezomib/p53 delivery and apoptosis induction.

•Mutations of p53 gene is closely correlated with tumor progression.•Gene therapy can effectively recover tumor suppressor ability of p53.•The change of p53 status substantially enhanced the p53-mediated sensitivity of BTZ.•UCL-guided image facilitated the real-time detection of drug and gene delivery.•The conjunction of H2A enhance biocompatibility and transfection efficiency.