Development of a Quantitative Relationship Between CAR-affinity, Antigen Abundance, Tumor Cell Depletion and CAR-T Cell Expansion Using a Multiscale Systems PK-PD Model
mAbs（2019）
Key words
Physiologically-based pharmacokinetic models,chimeric Antigen receptor T cells,cytokine release,immuno-oncology,tumor growth inhibition (TGI),cell-level models,global sensitivity analysis
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