Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and AKT/mTOR signaling pathway.

Urolithin A (UroA) is the main intestinal microflora metabolite derived from ellagic acid of pomegranate and some other antidiabetic traditional chinese herbals such as emblica officinalis, fructus chebulae, etc. In this study, the effect of UroA against diabetes and pancreatic damage via autophagic signaling was investigated. The outcomes of the experiments showed that UroA restored the autophagic clearance process and regulated AKT/mTOR signal in the pancreas of type 2 diabetic model mice, thus decreased oxidation in, flammation and apoptosis in the pancreas.Image 1