Structural and DNA Binding Properties of Mycobacterial Integration Host Factor mIHF.

Nina T Odermatt,Moreno Lelli,Torsten Herrmann,Luciano A Abriata,Aleksandre Japaridze,Hubert Voilquin,Rajkumar Singh,Jérémie Piton,Lyndon Emsley,Giovanni Dietler,Stewart T Cole

Journal of Structural Biology（2020）

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摘要

•The structure of mIHF was solved by solution NMR spectroscopy.•mIHF is an alpha-helical protein with two DNA-binding sites.•mIHF introduces left-handed loops into DNA.•DNA unwinds and re-compacts in a mIHF-level dependent manner.

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关键词

mIHF,DBS,dsDNA,NAP,ssDNA

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