Berberine reduces inflammation of human dental pulp fibroblast via miR-21/KBTBD7 axis.
Archives of Oral Biology（2020）
Abstract
•LPS induces inflammatory response in HDPF.•BBR promotes proliferation of LPS-HDPF and ameliorates inflammation.•BBR down-regulates miR-21 while up-regulates KBTBD7 expression in LPS-HDPF.•miR-21 negatively targets KBTBD7.•BBR suppresses inflammation in LPS-HDPF through NF-κB signaling pathway.
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Key words
Human dental pulp fibroblast,Berberine,miR-21,KBTBD7,NF-κB signal pathway
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