Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model.
International Immunopharmacology（2020）
Abstract
•PDX inhibited the IL-1β-induced inflammatory response and ECM degradation in rat chondrocytes.•The anti-inflammatory mechanism of PDX could be the AMPK/NF-κB pathway.•PDX ameliorated osteoarthritis progression in a rat model.•PDX may be a potential therapeutic agent in OA treatment.
MoreTranslated text
Key words
Osteoarthritis (OA),Protectin DX (PDX),AMP-activated protein kinase (AMPK),Nuclear factor-κB (NF-κB),Chondrocyte
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined