Analysis Of The Vaccine-Induced Influenza B Virus Hemagglutinin-Specific Antibody Dependent Cellular Cytotoxicity Response.

Rory D de Vries,Nella J Nieuwkoop,Florian Krammer,Branda Hu,Guus F Rimmelzwaan

Virus Research（2020）

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摘要

•Seasonal inactivated influenza vaccines induce HA-head- and HA-stalk-specific antibodies that mediate ADCC.•A quadrivalent influenza vaccine induces antibodies to HA from both IBV lineages.•A trivalent vaccine containing HA from the B/Vic-lineage induces antibodies that cross-react with HA from the B/Yam lineage.•Cross-reactive antibodies are mainly directed to the HA-stalk.

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关键词

Influenza_B_Virus,Hemagglutinin,Antibodies,Natural_Killer_Cells,Antibody-Dependent_Cellular_Cytotoxicity

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