Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives.

Gentao Li,Ruicong Ma,Yufeng Xing,Jing Wei,Yajuan Bi,Caiyu Li,Hui Xiong,Kim K Baldridge,Jianhui Huang,Jay S Siegel,Youcai Zhang

Toxicology Letters（2020）

引用 3|浏览16

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摘要

•COR causes less cytotoxic responses than benzo[a]pyrene in hepatoma cells.•COR is a weak inducer of aryl hydrocarbon receptor (AhR).•AhR mediates the induction of cytochrome P450 1 isozymes by COR.•Derivatization alters the cytotoxicity of COR and its binding with AhR.

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关键词

Polycyclic aromatic hydrocarbons,Corannulene,Benzo[a]pyrene,Aryl hydrocarbon receptor

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