LncRNA ANRIL promotes cell proliferation, migration and invasion during acute myeloid leukemia pathogenesis via negatively regulating miR-34a.

Cheng-Hong Wang,Qian-Yuan Li,Lu Nie, Jie Ma,Chen-Jiao Yao,Fang-Ping Chen

The International Journal of Biochemistry & Cell Biology（2020）

引用 25|浏览20

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摘要

ANRIL promotes AML development through HDAC1-mediated epigenetic suppression of ASPP2 via negatively regulating miR-34a, which might serve as a therapeutic target for AML treatment.

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关键词

AML,ANRIL,ASPP2,CCK-8,CDX,ChIP,E2 F1,FACS,HDAC1,lncRNAs,miRNAs,PRC2

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