Ticagrelor Improves Remodeling, Reduces Apoptosis, Inflammation and Fibrosis and Increases the Number of Progenitor Stem Cells After Myocardial Infarction in a Rat Model of Ischemia Reperfusion.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology(2019)
Abstract
Ticagrelor attenuated adverse remodeling and deterioration of left ventricular systolic function despite starting treatment after the myocardial ischemia-reperfusion injury is completed. Aspirin had similar effects; however, when combined with ticagrelor, the protective effects were significantly attenuated. Ticagrelor increased the levels of several markers of stem cells and regeneration, suggesting cardiac healing by recruiting regenerative cells into the infarct.
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Key words
Apoptosis, Aspirin, Fibrosis, Inflammation, Ischemia-reperfusion, Prasugrel, Remodeling, Stem cells, Ticagrelor
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