Lipidated α/Sulfono-α-AA heterogeneous peptides as antimicrobial agents for MRSA.

Sylvia Singh,Minghui Wang,Ruixuan Gao,Peng Teng,Timothy Odom,En Zhang,Hai Xu,Jianfeng Cai

Bioorganic & Medicinal Chemistry（2020）

引用 9|浏览14

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摘要

•Design and synthesis of 13 lipidated α/Sulfono-α-AA heterogeneous peptides as mimics for Host defense peptides.•Lipidated α/Sulfono-α-AA heterogeneous peptides can efficiently eradicate Gram-positive bacteria.•Synthesized lipidated α/Sulfono-α-AA heterogeneous peptides capable of selecting bacterial cells over human red blood cells.

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关键词

Host Defense Peptides,Peptidomimetics,Bacterial resistance,Lipidation,Antimicrobial

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