The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of αKlotho.

Risul Amin,Rui He,Dhanu Gupta,Wenyi Zheng,Mikhail Burmakin,Dara K Mohammad,Joseph W DePierre,Behnam Sadeghi,Hannes Olauson,Annika Wernerson,Samir El-Andaloussi,Moustapha Hassan,Manuchehr Abedi-Valugerdi

International Immunopharmacology（2020）

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摘要

•Onset of acute graft-versus-host disease (aGVHD) induces kidney injury.•aGVHD-induced kidney injury involves up-regulation of renal NGAL protein.•aGVHD-induced kidney injury involves accumulation of lysosomes in proximal tubules.•aGVHD-induced kidney injury involves down-regulation of renal αKlotho.•aGVHD-induced kidney injury involves increases in circulatory Fgf23.

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关键词

Acute graft versus host disease,Fibroblast growth factor 23,αKlotho,Hematopoietic stem cell transplantation,Interferon gamma,Kidney injury,Lysosome,Tumor necrosis factor alpha

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