Sleep Disturbance: An Early Sign of Alzheimer’s Disease

Alzheimer’s disease （AD） is a progressive neurodegenerative disorder associated with cognitive impairment in older adults. The accumulation of insoluble forms of amyloid-b （Ab） in plaques in extracellular spaces and the aggregation of hyperphosphorylated microtubule-associated protein tau in neurofibrillary tangles in neurons are