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Structure Elucidation and Formation Mechanistic Study of a Methylene-Bridged Pregabalin Dimeric Degradant in Pregabalin Extended-Release Tablets

Yun Tian,Jinsheng Lin,Feifei Chen,Shaolan Wang,Dan Li,Zijian Kuang,Wenquan Zhu, Yue Li, Terry Zheng, Wei Cao, Bob Zhu, Eric Tsai,Lei Fu,Min Li

INTERNATIONAL JOURNAL OF PHARMACEUTICS（2020）

Cited 11|Views20
Key words
Pregabalin extended-release tablets,Formaldehyde,Dimerization,LC-MS,Compatibility study,Stability study
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