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Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer

Yanjing Li,Yiping He,William Butler,Lingfan Xu,Yan Chang,Kefeng Lei,Hong Zhang,Yinglu Zhou,Allen C. Gao,Qingfu Zhang, Daniel G. Taylor,Donghui Cheng,Suzette Farber-Katz,Rachid Karam,Tyler Landrith,Bing Li,Sitao Wu,Vickie Hsuan,Qing Yang,Hailiang Hu,Xufeng Chen, Melissa Flowers,Shannon J. McCall,John K. Lee,Bryan A. Smith,Jung Wook Park,Andrew S. Goldstein,Owen N. Witte,Qianben Wang,Matthew B. Rettig,Andrew J. Armstrong,Qing Cheng,Jiaoti Huang

Science Translational Medicine（2019）

Cited 57|Views25
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Abstract
Cellular heterogeneity of PCa contributes to hormonal therapy failure, but CXCR2 on neuroendocrine cells is a potential therapeutic target.
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