Variation of the CD4, CD8, and MHC II cell population in granulomas of immunocompetent and immunosuppressed rabbits in Encephalitozoon cuniculi infection.

A Soto-Domínguez,C Dávila-Martínez,U Castillo-Velázquez, A M Nevárez-Garza,H Rodríguez-Rocha, O Saucedo-Cárdenas, A Y Arce Mendoza,J J Zarate-Ramos,L E Rodríguez-Tovar

Comparative Immunology, Microbiology and Infectious Diseases（2020）

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摘要

•CD4-positive cells mainly present in brain and kidneys of immunosuppressed rabbits.•CD8-positive cells mainly present in kidneys of immunosuppressed rabbits.•MHCII cells more predominant in brain of immunocompetent rabbits.•Change in phenotype of Th1- to Th2-like in brain and kidneys granulomas by an unknown mechanism.

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关键词

CD4,CD8,CW,H&E,IHC,MTB

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