Next generation sequencing of human enterovirus strains from an outbreak of enterovirus A71 shows applicability to outbreak investigations.

Sacha Stelzer-Braid,Matthew Wynn,Richard Chatoor,Matthew Scotch,Vidiya Ramachandran,Hooi-Ling Teoh,Michelle A Farrar,Hugo Sampaio,Peter Ian Andrews,Maria E Craig,C Raina MacIntyre,Hemalatha Varadhan,Alison Kesson,Philip N Britton,James Newcombe,William D Rawlinson

Journal of Clinical Virology（2020）

引用 5|浏览54

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摘要

•Near full-length genome analysis using next generation sequencing identified EV-A71 and other enterovirus A and B subtypes circulating.•The Sydney EV-A71 2013 strain was very similar to EV-A71 circulating in China and Vietnam during the previous year.•Strains causing more severe clinical manifestations grouped together phylogenetically.

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关键词

Enterovirus,EV-A71,Phylogeny,Hand, foot and mouth disease,Whole genome sequencing,Australia

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