Genetic susceptibility to hepatic sinusoidal obstruction syndrome in pediatric patients undergoing HSCT.
Biology of Blood and Marrow Transplantation（2020）
摘要
•Sinusoidal obstruction syndrome (SOS) is a complication of hematopoietic stem cell transplantation.•Whole-exome sequencing was performed to identify the genetic contribution to SOS.•Exome-wide association study identified 8 lead signals in the discovery cohort.•Three loci (UGT2B10, BHLHE22, and KIAA1715) were validated in the replication group.•The finding can be useful for designing personalized prophylactic strategies.
更多查看译文
关键词
Hepatic sinusoidal obstruction syndrome,Hematopoietic stem cell transplantation,Busulfan,Genetic factors,Association study,Whole-exome sequencing
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要