P1.11-26 The Epidemiology of Ground Glass Opacity (GGO) Lung Adenocarcinoma: A Network Based Cumulative Meta-Analysis

An increasing number of early-stage NSCLC with ground glass opacity (GGO) have been detected with lung cancer screening. GGO lung cancer is considered as a low-grade adenocarcinoma with non-invasive or minimally invasive growth patterns. The long term survival for GGO lung cancer is very much better compared to the solid counterparts. In this study, we investigate the epidemiological data of GGO lung cancer and outline the variation tendency through cumulative meta-analysis. Two individual researchers conducted the platform searches on the PubMed, Cochrane Library and Embase from the inception dates to Dec. 1st, 2018. For counting data, such as number of female and non-smoking patients, the single rate is determined along with the corresponding 95% confidence interval (CI). For measurement data, such as average diagnosis age of patients, the single mean value is determined along with the corresponding 95% confidence interval (CI). We performed cumulative meta-analysis and metatrend analysis for the epidemiology data. Data analyses was performed using the Stata version 13.0 (Stata Corp LLC, College Station, Texas, USA). A meta-analysis from a total of 50 articles with 8565 GGO patients between 1977 and 2018 showed that the rate of female GGO lung cancer was 0.62. The average age of all GGO lung cancer patients was 62.10 and the cumulative meta-analysis showed the average age has been decreasing from 66.40 to 59.06 which variation tendency was statistically significant (p<0.05). From 21 articles included smoking status of 4262 GGO lung cancers, it showed that the total rate for non-smoking patients was 0.72 and there was a significant increasing tendency (0.65 to 0.79, p<0.05). Our analysis indicates that there are much more GGO lung cancers in females compared to males. In recent years, it showed the average age of GGO lung cancer patients has been declined prominently while the non-smoking rate significantly increased. This investigation has challenged the current criteria of lung cancer screening which excludes a huge population of younger and non-or light-smoking patients who may have GGO lung cancers. Further study has to set up a more refined model which contributes to detect early stage NSCLC with GGO manifestation, which would significantly decrease the mortality of lung cancer.