Eczematous eruption after guselkumab treatment for psoriasis

Psoriasis vulgaris is a chronic inflammatory skin disorder presenting in genetically predisposed individuals. In the last decades, numerous biologics were approved for the treatment of psoriasis. These include tumor necrosis factor (TNF)-α inhibitors, therapeutic antibodies that inhibit the p40 subunit shared by interleukin (IL)-12 and -23, and IL-17 inhibitors. A recent asset in the therapeutic arsenal for psoriasis is guselkumab (Tremfya; Janssen-Cilag, Beerse, Belgium), a high-affinity inhibitor of the p19 subunit of IL-23 with clinically proven superiority compared with ustekinumab.