A New Heterometallic Mof In Cyanosilylation Reaction, Treatment And Care Management Value In Stroke By Reducing Oxidative Stress Damage

By employment the heterometallic strategy, a new highly porous metal-organic framework {(Me2NH2)[Mn3K2(TZIA)(3)-(H2O)(3)]center dot(DMF)(4)}(n)(1) was prepared via corresponding K(I)and Mn(II) salts and hetero-donor organic ligand 5-(1H-tetrazol-5yl)isophthalic acid (H(3)TZIA) via solvothermal conditions in water and DMF mixed solvent. X-ray study of a single crystal shows that ionic K+ was immobilized on the surface of pores via trinuclear Mn2+-tetrazole coordination motif. The resulting activated 1a has been explored in detail by BET analysis to probe its porosity. The removal of water molecules in order to generate 1a makes it possible for K+ ions to be applied as an efficient and size-selective multiphase catalyst for cyano-silylation of acetaldehyde under the mild conditions without solvent. Furthermore, ELISA assay was performed to measure IL-18 and IL-1 beta level in hCMEC/D3 human brain microvascular endothelial cells after compound treatment. Besides, ROS detection and RT-PCR was performed to detect ROS production as well as the related gene expression. Next, the protective effect of the compound was evaluated in animal model in vivo.