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Dynamic Bh3 Profiling Reveals Novel Therapeutic Strategies For The Treatment Of Double-Hit Lymphoma

Jennifer Crombie,Chen Lossos,Kristopher Sarosiek,Amanda L Christie,Cameron Fraser,Shruti Bhatt,Jing Deng,Matthew S. Davids,David M. Weinstock,Anthony Letai

BLOOD（2017）

Cited 2|Views28
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Abstract
Introduction: Double-hit lymphomas (DHL), a subset of diffuse large B-cell lymphoma (DLBCL) harboring both a MYC and BCL-2 or BCL-6 gene rearrangement, are associated with rapidly progressive disease that is often refractory to aggressive therapy. Given these poor outcomes, novel therapeutic strategies and drug combinations are desperately needed.
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Key words
dynamic bh3 profiling,novel therapeutic strategies,double-hit
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