Substituted 2-(2-Arylethenyl)quinazolines. Synthesis and Structure

A. A. Harutyunyan, G. T. Gukasyan,H. A. Panosyan,R. A. Tamazyan,A. G. Ayvazyan,G. G. Danagulyan

Russian Journal of Organic Chemistry（2019）

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摘要

The reaction of 2-methyl-4 H -3,1-benzoxazin-4-one and its 6-iodo derivatives with a number of amines in polyphosphoric acid afforded 3- and 3,6-substituted 2-methylquinazolin-4(3 H )-ones. The latter reacted with aromatic and heterocyclic aldehydes under solvent-free conditions to give 2-[( E )-2-arylethenyl]-quinazolin-4(3 H )-ones. The structure of the synthesized compounds was confirmed by two-dimensional 1 H– 1 H NOESY data and X-ray analysis.

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关键词

2-methyl-4H-3,1-benzoxazin-4-one, pharmacophoric amines, 3- and 6-substituted (unsubstituted) 2-methylquinazolin-4(3H)-ones, aryl(hetaryl)carbaldehydes, 2-[(E)-2-arylethenyl]quinazolin-4(3H)-ones

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