2522. Prescription Drug Use Among Women with HIV Who Are of Childbearing Potential

Abstract Background In the context of medication safety, women with HIV who are of childbearing potential represent a particular challenge given the prevalence of unplanned pregnancies. Despite this, significant gaps in the literature exist characterizing prescription drug use in this cohort. Our study describes medication use and identifies medications that are contraindicated during pregnancy in a cohort of women with HIV who are of childbearing age. Methods Women with HIV aged 18–45 years who presented to an academic medical center between January 2016 and December 2017 were included for analysis. Patients were excluded if they were prescribed any form of contraception, received permanent sterilization, or were post-menopausal. The number of individual medications prescribed in the electronic medical record during the study period were documented. Chronic medications, defined as those prescribed for longer than 3 months, were analyzed. Patients were identified as experiencing polypharmacy if prescribed 5 or more medications at one time. In addition, contraindicated medications were reviewed and documented. Results A total of 213 patients met inclusion criteria for review. Of these, 169 (79%) and 66 (31%) patients experienced polypharmacy when including and excluding antiretrovirals, respectively. When antiretrovirals were included the mean number of medications prescribed was 7.48 (SD = 3.87) and 3.92 (SD = 3.75) when excluded. Of the 213 patients included, 64 (30%) were prescribed medications contraindicated during pregnancy. The majority of contraindicated medications were angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins, and hydroxyzine. In this cohort of women of child bearing potential (WOCBP) only 60 patients (28%) had been prescribed prenatal vitamins. Conclusion In this cohort of WOCBP with HIV, polypharmacy was observed in the majority of women. In addition, a third of these women were prescribed medications that are contraindicated during pregnancy. Given the potential impact of contraindicated medications on the developing fetus, our data supports the importance of preconception counseling on this issue as well as understanding the potential safety implications for mother and the fetus. Disclosures All authors: No reported disclosures.