Evaluation of dengue serological tests available in Puerto Rico for identification of prior dengue infection for pre-vaccination screening

Matthew Bonaparte,James Huleatt,Shekema Hodge,Lingyi Zheng,Yaniv Lustig,Carlos A. DiazGranados,Yasemin Ataman-Önal,Stephen Savarino

Diagnostic Microbiology and Infectious Disease（2020）

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摘要

We assessed a dengue IgG rapid diagnostic test (RDT) and IgG enzyme-linked immunosorbent assay (ELISA) to determine their suitability for dengue prevaccination screening. Each exhibited ≥99% specificity. The RDT demonstrated no Zika cross-reactivity, while the ELISA displayed greater sensitivity. Both could safely guide vaccination in Puerto Rico pending availability of improved serotests.

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关键词

CLIA,CYD-TDV,ELISA,EU,FDA,JE,NS1,PDI,PRNT,RDT,RT-PCR,VCD,WNV,YF

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